MovDisordV3, Main, Exploration, bibRecord, 001024

Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk

Identifieur interne : 001024 ( Main/Exploration ); précédent : 001023; suivant : 001025

Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk

Auteurs : Marc G. Weisskopf [États-Unis] ; Paul Knekt [Finlande] ; Eilis J. O'Reilly [États-Unis] ; Jukka Lyytinen [Finlande] ; Antti Reunanen [Finlande] ; Francine Laden [États-Unis] ; Larisa Altshul [États-Unis] ; Alberto Ascherio [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0017932

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Facteur risque, Epidémiologie, Prospective, Toxicologie.
Wicri :
- topic : Prospective, Toxicologie.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Epidemiology, Female, Humans, Logistic Models, Male, Middle Aged, Nervous system diseases, Parkinson Disease (blood), Parkinson Disease (epidemiology), Parkinson disease, Polychlorinated Biphenyls (blood), Prospective, Prospective Studies, Retrospective Studies, Risk factor, Toxicology, Young Adult.
MESH :
- chemical , blood : Polychlorinated Biphenyls.
- blood : Parkinson Disease.
- epidemiology : Parkinson Disease.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Logistic Models, Male, Middle Aged, Prospective Studies, Retrospective Studies, Young Adult.

Abstract

Evidence suggests possible Parkinson's disease (PD)-relevant neural effects of exposure to polychlorinated biphenyls. Limited epidemiological evidence suggests that polychlorinated biphenyl exposure may increase PD risk, but no studies have involved biomarkers of polychlorinated biphenyl exposure before PD onset. We examined the prospective association between serum polychlorinated biphenyls and PD. We conducted a nested case-control study within the Finnish Mobile Clinic Health Examination Survey with serum samples collected during 1968-1972 and analyzed in 2005-2007 for polychlorinated biphenyls. Incident PD cases were identified through the Social Insurance Institution's registry and were confirmed by medical record review (n = 101). Controls (n = 349) were matched on age, sex, municipality, and vital status. We used logistic regression to estimate adjusted odds ratios. There was no evidence of increasing risk of PD with increasing polychlorinated biphenyl exposure in adjusted analyses. Instead, there was a trend toward lower odds of PD with increasing serum polychlorinated biphenyl concentrations, which was most pronounced for the sum of all measured polychlorinated biphenyl congeners and the sum of dioxin-like congeners. Compared with that of those in the lowest quintile, the odds ratio of PD among those in the highest quintile of total polychlorinated biphenyls was 0.29 (95% confidence interval, 0.12-0.70; P trend = .02) and for dioxin-like congeners was 0.34 (95% confidence interval, 0.13-0.90; P trend = .05). These results do not support an increased risk of PD from polychlorinated biphenyl exposure and instead suggest a possible protective effect of polychlorinated biphenyl exposure.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510340

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk</title>
<author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute for Health and Welfare</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>National Institute for Health and Welfare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Reilly, Eilis J" sort="O Reilly, Eilis J" uniqKey="O Reilly E" first="Eilis J." last="O'Reilly">Eilis J. O'Reilly</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Nutrition, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lyytinen, Jukka" sort="Lyytinen, Jukka" uniqKey="Lyytinen J" first="Jukka" last="Lyytinen">Jukka Lyytinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reunanen, Antti" sort="Reunanen, Antti" uniqKey="Reunanen A" first="Antti" last="Reunanen">Antti Reunanen</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute for Health and Welfare</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>National Institute for Health and Welfare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Altshul, Larisa" sort="Altshul, Larisa" uniqKey="Altshul L" first="Larisa" last="Altshul">Larisa Altshul</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Environmental Health & Engineering</s1>
<s2>Needham, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Nutrition, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0017932</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 13-0017932 INIST</idno>
<idno type="RBID">Pascal:13-0017932</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000038</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002C76</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000097</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Weisskopf M:polychlorinated:biphenyls:in</idno>
<idno type="wicri:Area/Main/Merge">001076</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510340</idno>
<idno type="RBID">PMC:3510340</idno>
<idno type="wicri:Area/Pmc/Corpus">000294</idno>
<idno type="wicri:Area/Pmc/Curation">000294</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000169</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000C09</idno>
<idno type="wicri:Area/PubMed/Curation">000C09</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C84</idno>
<idno type="wicri:Area/Ncbi/Merge">003853</idno>
<idno type="wicri:Area/Ncbi/Curation">003853</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003853</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Weisskopf M:polychlorinated:biphenyls:in</idno>
<idno type="wicri:Area/Main/Merge">000C74</idno>
<idno type="wicri:Area/Main/Curation">001024</idno>
<idno type="wicri:Area/Main/Exploration">001024</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk</title>
<author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute for Health and Welfare</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>National Institute for Health and Welfare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Reilly, Eilis J" sort="O Reilly, Eilis J" uniqKey="O Reilly E" first="Eilis J." last="O'Reilly">Eilis J. O'Reilly</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Nutrition, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lyytinen, Jukka" sort="Lyytinen, Jukka" uniqKey="Lyytinen J" first="Jukka" last="Lyytinen">Jukka Lyytinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reunanen, Antti" sort="Reunanen, Antti" uniqKey="Reunanen A" first="Antti" last="Reunanen">Antti Reunanen</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Institute for Health and Welfare</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>National Institute for Health and Welfare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Altshul, Larisa" sort="Altshul, Larisa" uniqKey="Altshul L" first="Larisa" last="Altshul">Larisa Altshul</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Environmental Health, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Environmental Health & Engineering</s1>
<s2>Needham, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Nutrition, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Epidemiology</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson disease</term>
<term>Polychlorinated Biphenyls (blood)</term>
<term>Prospective</term>
<term>Prospective Studies</term>
<term>Retrospective Studies</term>
<term>Risk factor</term>
<term>Toxicology</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Polychlorinated Biphenyls</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Facteur risque</term>
<term>Epidémiologie</term>
<term>Prospective</term>
<term>Toxicologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term>
<term>Toxicologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence suggests possible Parkinson's disease (PD)-relevant neural effects of exposure to polychlorinated biphenyls. Limited epidemiological evidence suggests that polychlorinated biphenyl exposure may increase PD risk, but no studies have involved biomarkers of polychlorinated biphenyl exposure before PD onset. We examined the prospective association between serum polychlorinated biphenyls and PD. We conducted a nested case-control study within the Finnish Mobile Clinic Health Examination Survey with serum samples collected during 1968-1972 and analyzed in 2005-2007 for polychlorinated biphenyls. Incident PD cases were identified through the Social Insurance Institution's registry and were confirmed by medical record review (n = 101). Controls (n = 349) were matched on age, sex, municipality, and vital status. We used logistic regression to estimate adjusted odds ratios. There was no evidence of increasing risk of PD with increasing polychlorinated biphenyl exposure in adjusted analyses. Instead, there was a trend toward lower odds of PD with increasing serum polychlorinated biphenyl concentrations, which was most pronounced for the sum of all measured polychlorinated biphenyl congeners and the sum of dioxin-like congeners. Compared with that of those in the lowest quintile, the odds ratio of PD among those in the highest quintile of total polychlorinated biphenyls was 0.29 (95% confidence interval, 0.12-0.70; P trend = .02) and for dioxin-like congeners was 0.34 (95% confidence interval, 0.13-0.90; P trend = .05). These results do not support an increased risk of PD from polychlorinated biphenyl exposure and instead suggest a possible protective effect of polychlorinated biphenyl exposure.</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
</region>
<name sortKey="Altshul, Larisa" sort="Altshul, Larisa" uniqKey="Altshul L" first="Larisa" last="Altshul">Larisa Altshul</name>
<name sortKey="Altshul, Larisa" sort="Altshul, Larisa" uniqKey="Altshul L" first="Larisa" last="Altshul">Larisa Altshul</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name>
<name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name>
<name sortKey="Laden, Francine" sort="Laden, Francine" uniqKey="Laden F" first="Francine" last="Laden">Francine Laden</name>
<name sortKey="O Reilly, Eilis J" sort="O Reilly, Eilis J" uniqKey="O Reilly E" first="Eilis J." last="O'Reilly">Eilis J. O'Reilly</name>
<name sortKey="O Reilly, Eilis J" sort="O Reilly, Eilis J" uniqKey="O Reilly E" first="Eilis J." last="O'Reilly">Eilis J. O'Reilly</name>
<name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
</country>
<country name="Finlande"><noRegion><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name>
</noRegion>
<name sortKey="Lyytinen, Jukka" sort="Lyytinen, Jukka" uniqKey="Lyytinen J" first="Jukka" last="Lyytinen">Jukka Lyytinen</name>
<name sortKey="Reunanen, Antti" sort="Reunanen, Antti" uniqKey="Reunanen A" first="Antti" last="Reunanen">Antti Reunanen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001024 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001024 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0017932
   |texte=   Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk

Polychlorinated Biphenyls in Prospectively Collected Serum and Parkinson's Disease Risk

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.